To compare the effects of atracurium, 0.75 mg/kg, on the mean arterial pressures, heart rates and plasma histamine levels under 2%-enflurane inhalation with mask, 24 patients were allocated randomly into two groups; one(Group I, n=12) which the
slow
injection for 75 seconds.
In both groups, there are the most significant decreases and the recovery in mean arterial pressure 1~2 min and 5 min after atracurium, respectively. Group I showed a significant decrease of mean arterial pressure about 10% more than Group II. In
heart
rate, there are the significant decreases gradually to 87~88% of control 5 min after atracurium in both groups except the only significant increase(104%) 1 min after atracurium in Group 1. And group I showed a significant increase(200%) in plasma
histamine concentration (p<0.05) 2 min after injection than before, but Group II did no significant change.
In conclusion, the slow injection of atracurium over 75s during induction of anesthesia can attenuate the histamine-induced cardiovascular response. (Korean J Anesthesiol 1995; 29: 238~243)
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